Levetiracetam at concentrations of up to 10 µM did not demonstrate binding affinity for a variety of known receptors, such as those associated with benzodiazepines, GABA (gamma-aminobutyric acid), glycine, NMDA (N-methyl-D-aspartate), re-uptake sites, and second messenger systems. Furthermore, in vitro studies have failed to find an effect of levetiracetam on neuronal voltage-gated sodium or T-type calcium currents and levetiracetam does not appear to directly facilitate GABAergic neurotransmission. However, in vitro studies have demonstrated that levetiracetam opposes the activity of negative modulators of GABA- and glycine-gated currents and partially inhibits N-type calcium currents in neuronal cells.
I know how ya feel. I am taking Keppra,1600mgs in AM and 1600mgs in PM,along with a 1000mg dose of Neurontin 3x. It makes my temper very short. I cannot take people who are talking 90to nothing and always have a friend who is constantly talking,and I feel lke telling him to shut the (*&^ up at times, also have to deal with heel spurs,and my only way to get around without depending on others id walk. After a block or so,it feels like lightening bolts going up my calves to my thighs. Can't drive due to this condition. Makes you wonder just what you did to get dealt this hand. Its not fair!
On July 10, 2008, an advisory panel was convened by the Food and Drug Administration (FDA) to review data that the FDA had previously collected from drug studies showing an association between many of the antiepileptic drugs (AEDs) and suicidal ideation and behavior, which together are called suicidality. According to the FDA’s Alert, among the patients with epilepsy in these drug studies, 1 out of 1000 people taking the placebo (inactive substance) showed suicidality compared to approximately out of 1000 people who took an AED. The FDA advisory panel voted to accept the FDA's data at its meeting on July 10. The FDA has provided the following information for patients, family members, and caregivers at http:///Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/.