Fifty-nine healthy volunteers were included (22 of which were smokers). Fifteen smokers remained abstinent for a month. Both groups were similar except in age, being smokers older. Male smokers had lower lumbar BMD (p = ). After adjusting by age, serum leptin levels were higher in smokers than in non-smokers, with statistical differences in women (p = ). Abstinence increased leptin levels, though not reaching statistical significance. An inverse correlation between leptin levels and androstendione in men (r = -; p = ), and a positive correlation with testosterone in women (r = ; p = ) were found. After adjusting by body mass index, only the correlation of leptin levels with androstendione persisted.