Keloids were described by Egyptian surgeons around 1700 BCE, recorded in the Smith papyrus, regarding surgical techniques. [ citation needed ] Baron Jean-Louis Alibert (1768–1837) identified the keloid as an entity in 1806. [ citation needed ] He called them cancroïde , later changing the name to chéloïde to avoid confusion with cancer. The word is derived from the Greek χηλή , chele , meaning " hoof ", here in the sense of "crab pincers ", and the suffix -oid , meaning "like".
Meshkinpour et al (2005) examined the safety and effectiveness of the ThermaCool TC radiofrequency system for treatment of hypertrophic and keloid scars and assessed treatment associated collagen changes. Six subjects with hypertrophic and 4 with keloid scars were treated with the ThermaCool device: 1/3 of the scar received no treatment (control), 1/3 received one treatment and 1/3 received 2 treatments (4-week interval). Scars were graded before and then 12 and 24 weeks after treatment on symptoms, pigmentation, vascularity, pliability, and height. Biopsies were taken from 4 subjects with hypertrophic scars and evaluated with hematoxylin and eosin (H & E) staining, multi-photon microscopy, and pro-collagen I and III immunohistochemistry. No adverse treatment effects occurred. Clinical and H & E evaluation revealed no significant differences between control and treatment sites. Differences in collagen morphology were detected in some subjects. Increased collagen production (type III > type I) was observed, appeared to peak between 6 and 10 weeks post-treatment and had not returned to baseline even after 12 weeks. The authors concluded that use of the thermage radiofrequency device on hypertrophic scars resulted in collagen fibril morphology and production changes. ThermaCool alone did not achieve clinical hypertrophic scar or keloid improvement. They noted that the collagen effects of this device should be studied further to optimize its therapeutic potential for all indications.
Keloids can develop following the minor injuries that occur with body piercing. Since this form of physical adornment has become popular, the presence of keloidal scarring is much more prevalent. Since doctors do not understand the precise reasons why some people are more prone to developing keloids, it is impossible to predict whether one's first piercing will lead to keloid formation. Although there are some families that seem prone to forming keloids, for the most part, it's impossible to tell who will develop a keloid. One person might, for instance, develop a keloid in one earlobe after piercing and not in the other. It makes sense, however, for someone who has formed one keloid to avoid any elective surgery or cosmetic piercing of any body part.